A side-by-side look at the Clinicaltrialsgov MCP Server and Aria MCP Server MCP servers: transport, auth, tools, quality signals, and the config to install either one in Claude, Cursor, Windsurf or VS Code.
Verdict: choose Clinicaltrialsgov MCP Server for biology, medicine and bioinformatics work as a local process; choose Aria MCP Server for biology, medicine and bioinformatics as a local process. You can also run both side by side in one mcpServers block.
clinicaltrials_search_studies, clinicaltrials_get_study_record, clinicaltrials_get_study_count.search_pubmed, search_clinical_trials, search_isrctn.Rows where the two servers differ are marked.
| Spec | ||
|---|---|---|
| Category | Biology, Medicine and Bioinformatics | Biology, Medicine and Bioinformatics |
| Quality signal | 61/100 · Good | 57/100 · Good |
| Install command | Confirmed | Confirmed |
| Transport | Local subprocess (stdio) | Local subprocess (stdio) |
| Auth | Not declared | No auth required |
| Pricing | Not declared | Free |
| Required env vars | None listed | None listed |
| Verified owner | Community listing | Community listing |
| GitHub stars | 99 | 3 |
| Directory activity | 1 views 0 installs 0 upvotes | 4 views 0 installs 0 upvotes |
| Tools | 7 | 3 |
| Full listing | View Clinicaltrialsgov MCP Server | View Aria MCP Server |
clinicaltrials_search_studiesSearch studies with full-text and field-specific queries, status/phase/geographic filters, pagination, sorting, and field selectionclinicaltrials_get_study_recordFetch a single study by NCT ID — full protocol record with optional location/outcome/reference capsclinicaltrials_get_study_countFast total study count for a query, without fetching dataclinicaltrials_get_field_valuesDiscover valid values for API fields, with per-value study countsclinicaltrials_get_field_definitionsResolve valid field names — keyword search, path drill-down, or top-level overviewclinicaltrials_get_study_resultsFetch posted results — outcomes, adverse events, participant flow, baseline — for completed studiesclinicaltrials_find_eligibleMatch patient demographics and conditions to candidate recruiting trials, without checking inclusion/exclusion criteriasearch_pubmedSearch PubMed for peer-reviewed biomedical literature. Read-only operation. No authentication required. Uses NCBI E-utilities public API (rate limit: ~3 requests/sec). Returns up to 10 results per call. No pagination. Returns 'No papers found.' if no results match. Use for: research papers, drug mechanisms, clinical outcomes, disease studies, safety/efficacy data, biomarkers, diagnostics, and any scientific question.search_clinical_trialsSearch ClinicalTrials.gov for clinical studies. Read-only operation. No authentication required. Uses ClinicalTrials.gov v2 public API (no rate limit documented). Returns up to 10 results per call. No pagination. Returns 'No clinical trials found.' if no results match. Use for: active trials, recruiting studies, inclusion/exclusion criteria, phase information, sponsor details, and trial locations.search_isrctnSearch the ISRCTN registry for UK and European clinical trials. Read-only operation. No authentication required. Complements ClinicalTrials.gov by covering trials at UK academic institutions and European research centers not listed on ClinicalTrials.gov. Returns up to 10 results per call, filtered for relevance. Returns 'No ISRCTN trials found.' if no results match. Use for: UK/European trials, academic institution studies, international coverage beyond ClinicalTrials.gov.Paste either block (or both) into your client config, e.g. claude_desktop_config.json or ~/.cursor/mcp.json. We only show a config when the install command is confirmed.
{
"mcpServers": {
"clinicaltrialsgov-mcp-server": {
"command": "bunx",
"args": [
"clinicaltrialsgov-mcp-server@latest"
]
}
}
}
{
"mcpServers": {
"pkotecha-eng-aria-mcp-server": {
"command": "uvx",
"args": [
"aria-mcp-server"
]
}
}
}