What is the key difference between ChatSpatial and Uniprot MCP?

ChatSpatial belongs to the Biology, Medicine and Bioinformatics category with local stdio execution, while Uniprot MCP belongs to the Biology, Medicine and Bioinformatics category with local stdio execution.

How do I install ChatSpatial or Uniprot MCP in Claude Desktop or Cursor?

Copy the mcpServers JSON configuration snippet provided on this page into your claude_desktop_config.json or ~/.cursor/mcp.json file and restart your AI client.

Are ChatSpatial and Uniprot MCP free or paid?

ChatSpatial operates under a Free / Open Source model (API Key required). Uniprot MCP operates under a Free / Open Source model (No auth required).

Which MCP server has more tools and community activity?

ChatSpatial lists 6 tools with 1 views and 44 GitHub stars. Uniprot MCP lists 41 tools with 3 views and 3 GitHub stars.

Can I use both ChatSpatial and Uniprot MCP together in the same MCP host?

Yes! MCP hosts like Claude Desktop, Cursor, Windsurf, Cline, and VS Code support configuring multiple servers under the mcpServers object simultaneously.

Side-by-Side Model Context Protocol Comparison

ChatSpatial vs Uniprot MCP

In-depth architectural comparison of the ChatSpatial and Uniprot MCP MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

At a Glance & Executive Verdict

ChatSpatial

Biology, Medicine and Bioinformatics · Local stdio

Quality: 53/100 (Good) | Auth: API Key required

Uniprot MCP

Biology, Medicine and Bioinformatics · Local stdio

Quality: 60/100 (Good) | Auth: No auth required

Verdict Summary: Choose ChatSpatial if you need specialized Biology, Medicine and Bioinformatics tools running via a local process. Choose Uniprot MCP if your workspace requires Biology, Medicine and Bioinformatics integration with local subprocess execution. Both servers can be configured concurrently in your client's mcpServers manifest.

Which MCP Server Should You Choose?

Choose ChatSpatial when:

You need dedicated capabilities in the Biology, Medicine and Bioinformatics domain.
You prefer local stdio subprocess transport architecture.
Your security boundary fits: API Key required (Free / Open Source).
You have access to required keys: CHATSPATIAL_API_KEY, CHATSPATIAL_CONFIG_PATH, CHATSPATIAL_HTTP_PORT, CHATSPATIAL_LOG_LEVEL.
Primary tools included: 20 MCP tools exposing 66 spatial transcriptomics methods, Schema-enforced orchestration for reproducible workflows, Supports 10x Visium, Xenium, Slide-seq v2, MERFISH, seqFISH data.

Explore ChatSpatial Details

Choose Uniprot MCP when:

You need dedicated capabilities in the Biology, Medicine and Bioinformatics domain.
You prefer local stdio subprocess transport architecture.
Your security boundary fits: No auth required (Free / Open Source).

Feature & Specification Comparison

Specification	ChatSpatial cafferychen777 Biology, Medicine and Bioinformatics	Uniprot MCP smaniches Biology, Medicine and Bioinformatics
Summary	MCP server for spatial transcriptomics analysis with 60+ integrated methods covering cell annotation, deconvolution, spatial statistics, and visualization.	Auditable UniProt MCP server: 41 tools over the UniProt knowledgebase (entries, features, variants, PTMs, GO terms, cross-references) with per-query SHA-256 provenance and offline replay. uvx uniprot-mcp-server
Category & Scope

Tools & Capabilities Breakdown

ChatSpatial Tools (6)

20 MCP tools exposing 66 spatial transcriptomics methods

Schema-enforced orchestration for reproducible workflows

Supports 10x Visium, Xenium, Slide-seq v2, MERFISH, seqFISH data

Multiple analysis categories including deconvolution, cell communication, and enrichment

Runs via STDIO or configurable Streamable HTTP interface

Maintains backward compatibility with older MCP protocol versions

Uniprot MCP Tools (41)

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

ChatSpatial Configuration

mcpServers (Claude Desktop / Cursor)

{
  "mcpServers": {
    "cafferychen777-chatspatial": {
      "command": "uvx",
      "args": [
        "--from"
      ],
      "env": {
        "CHATSPATIAL_API_KEY": "YOUR_CHATSPATIAL_API_KEY_HERE",
        "CHATSPATIAL_CONFIG_PATH": "YOUR_CHATSPATIAL_CONFIG_PATH_HERE",
        "CHATSPATIAL_HTTP_PORT": "YOUR_CHATSPATIAL_HTTP_PORT_HERE",
        "CHATSPATIAL_LOG_LEVEL": "YOUR_CHATSPATIAL_LOG_LEVEL_HERE"
      }
    }
  }
}

Uniprot MCP Configuration

mcpServers (Claude Desktop / Cursor)

{
  "mcpServers": {
    "smaniches-uniprot-mcp": {
      "command": "uvx",
      "args": [
        "uniprot-mcp-server"
      ],
      "env": {
        "UNIPROT_MCP_CACHE_DIR": "YOUR_UNIPROT_MCP_CACHE_DIR_HERE"
      }
    }
  }
}

Frequently Asked Questions

ChatSpatial is categorized under Biology, Medicine and Bioinformatics and uses a local stdio subprocess. In contrast, Uniprot MCP belongs to Biology, Medicine and Bioinformatics using local stdio subprocess. Select ChatSpatial when you need capabilities focused on biology, medicine and bioinformatics and Uniprot MCP when you require tools for biology, medicine and bioinformatics.

More alternatives to ChatSpatial More alternatives to Uniprot MCP Biology, Medicine and Bioinformatics category hub