🧬 ARIA Clinical Research MCP Server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.

Tools

Tool	Description
`search_pubmed`	Search 35M+ peer-reviewed papers via NCBI E-utilities
`search_clinical_trials`	Search 400K+ trials via ClinicalTrials.gov v2 API
`search_isrctn`	Search UK/European trials via ISRCTN registry

Prompts

Prompt	Description
`clinical-research-brief`	Comprehensive evidence + trial brief for a condition
`adverse-event-analysis`	Structured AE and safety profile for a drug
`trial-eligibility-checker`	Patient eligibility assessment across recruiting trials

Resources

Resource	Description
`info://aria`	Overview of ARIA capabilities and data sources
`reference://trial-phases`	Phase I–IV definitions and FDA special designations
`reference://high-impact-journals`	Curated high-impact journals by specialty
`reference://fda-databases`	FDA databases for drug, safety, and regulatory research

Example queries

Once connected, ask Claude:

"Search PubMed for ketogenic diet pediatric epilepsy outcomes"
"Find recruiting trials for lung cancer immunotherapy"
"What does the literature say about veliparib in ovarian cancer, and are there active trials?"
"Find UK and European trials for pediatric epilepsy via ISRCTN"

Quickstart

Terminal

pip install aria-mcp-server
aria-mcp-server

Connect to Claude Desktop

Add to ~/Library/Application Support/Claude/claude_desktop_config.json:

config.json

{
  "mcpServers": {
    "aria-clinical-research": {
      "command": "aria-mcp-server"
    }
  }
}

Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.

Data sources

PubMed — NCBI E-utilities (public API, no key required)
ClinicalTrials.gov — v2 REST API (public API, no key required)
ISRCTN — UK/European clinical trials registry (public API, no key required)

Tech stack

FastMCP — MCP server framework
Python 3.12+

Use cases

Life sciences researchers needing real-time literature access
Clinical trial coordinators checking eligibility and recruiting status
Drug discovery teams cross-referencing published evidence with active trials
Any Claude agent needing grounded biomedical knowledge

Project Structure

Code

aria-mcp-server/          ← root, where mcp-publisher runs
├── aria_mcp_server/      ← Python package
│   ├── __init__.py
│   ├── server.py
│   └── tools.py
├── server.json           ← MCP registry metadata
├── pyproject.toml
├── README.md
├── LICENSE
└── glama.json

Built by

Pooja Kotecha · dinq.me/pkotecha-eng