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Heor Agent MCP

by neptun2000

Runs auditable HEOR research, evidence synthesis, economic modeling, and HTA dossier workflows through MCP.

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Install Heor Agent MCP

Pick your client, then add it in one click or paste the config.

STDIONode.js
~/Library/Application Support/Claude/claude_desktop_config.json
claude_desktop_config.json
{
  "mcpServers": {
    "neptun2000-heor-agent-mcp": {
      "command": "npx",
      "args": [
        "-y",
        "heor-agent-mcp"
      ]
    }
  }
}

Settings → Developer → Edit Config, merge this into mcpServers, then fully quit and reopen Claude Desktop.

We couldn’t confirm it starts correctly

We ran the install command but it didn't respond within our test window — this can mean a slow first-time install rather than a real problem.

npx -y heor-agent-mcp

No response to initialize.

This is an experimental automated check and can have false negatives — missing environment variables, a slow cold install, etc. It doesn’t necessarily mean something’s wrong. Last checked 1mo ago.

Overview

The neptun2000/heor-agent-mcp MCP server provides tools for literature retrieval, evidence appraisal, indirect treatment comparisons, survival analysis, health economic modeling, and HTA dossier preparation. It searches medical sources including PubMed, NICE, CADTH, and ICER, while maintaining audit trails and supporting persistent project knowledge bases. Use it when pharmaceutical, biotech, CRO, or medical affairs workflows require structured evidence review and reimbursement analysis. Local MCP use is available through npm, while the hosted web interface requires a user-supplied Anthropic API key.

Use cases

  • Search clinical and HTA literature across medical sources
  • Screen studies and summarize risk of bias
  • Compare treatments using Bucher, NMA, MAIC, or STC methods
  • Run cost-effectiveness and budget-impact analyses
  • Draft evidence sections for NICE, EMA, FDA, or EU JCA submissions

Key features

  • Multi-source literature search with PRISMA-style audit trail
  • PICO screening and structured risk-of-bias assessment
  • Indirect treatment comparison and network meta-analysis workflows
  • Markov, partitioned-survival, and decision-tree economic models
  • HTA dossier drafting for multiple agencies
  • Persistent project knowledge base with wiki read/write tools

Tools17

What Heor Agent MCP lets your agent do. Expand a tool for its parameters.

Self-reported~409 tokens of context

Security & health

What it can reach and how reliably it runs — from our own checks, not the maintainer’s claims.

ActiveLast checked Today

Recent health check succeeded.

8/8 checks healthy over the last 80d

Supply-chain signal

No high-severity advisories surfaced by our automated scan.

Critical 0High 0Medium 0Low 0

Scanned 15d ago via OSV.dev · heor-agent-mcp (npm)

Adoption & maintenance

Factual signals from GitHub, npm, and our automated checks — not a rating.

GitHub stars11Stargazers on the source repository.
npm downloads706Package downloads in the last 30 days.
Last commit4mo agoMost recent push to the default branch.
Install checkInconclusiveDidn't respond in our test window — often a slow first install.
Tools exposed17Callable tools this server registers over MCP.
Directory activity4 viewsConfig copies, upvotes, and views on AllMCPs.

How Heor Agent MCP works

What neptun2000/heor-agent-mcp MCP server does

The neptun2000/heor-agent-mcp MCP server exposes an MCP toolset for health economics and outcomes research. Its capabilities cover the workflow from finding studies and screening abstracts through bias assessment, evidence-network construction, comparative effectiveness analysis, economic modeling, and HTA submission drafting.

Literature searches can query 44 medical data sources and produce a PRISMA-style audit trail. Evidence tools support PICO relevance scoring, study-design classification, Cochrane RoB 2, ROBINS-I, AMSTAR-2, GRADE-related summaries, Bucher comparisons, frequentist network meta-analysis, MAIC, STC, and feasibility checks for indirect treatment comparisons.

Economic analysis includes parametric survival fitting, Markov models, partitioned survival models, decision trees, probabilistic and one-way sensitivity analysis, cost-effectiveness acceptability curves, EVPI, EVPPI, QALYs, and evLYG. Other tools cover ISPOR-oriented budget impact modeling, EQ-5D value-set references, and drafts for NICE, EMA, FDA, IQWiG, HAS, and EU JCA submissions.

How it works

The server runs as a local Node.js MCP process and can communicate with MCP hosts over standard input/output. MCP clients call individual tools with structured inputs; some workflows can be chained, such as searching literature, screening results, assessing risk of bias, building an evidence network, and passing outputs into an HTA dossier.

Project tools provide a persistent workspace. A project can be initialized, files in its raw or wiki trees can be searched and read, and compiled evidence can be written to an Obsidian-compatible wiki. Citation URLs can be checked before results are presented.

Setup and configuration

The neptun2000/heor-agent-mcp MCP server requires Node.js 20 or later according to the installation notes. Install or run it with npx heor-agent-mcp. Claude Desktop uses an MCP configuration entry with npx as the command and heor-agent-mcp as its argument. The README also gives client-specific setup guidance for Claude Code, Cursor, Continue, and Cline.

For a local HTTP test, the documented command sets MCP_HTTP_PORT=8080 and starts the package. A request to /health should return a status response identifying the server and version. The HTTP test mode is separate from the stdio configuration used for the normal Claude and other MCP-client integrations.

The optional HEORAGENT_DISCLOSURE_LEVEL setting can override the default AI disclosure mode with off, standard, or submission. The hosted web UI is a separate access path and requires the user's Anthropic API key; the README identifies literature search and link validation as usable without API keys.

Tools and capabilities

  • Search medical literature with source-specific retrieval and audit information.
  • Screen abstracts using PICO relevance and study-design classification.
  • Assess risk of bias with RoB 2, ROBINS-I, or AMSTAR-2 frameworks.
  • Evaluate and perform Bucher, NMA, MAIC, and STC comparisons.
  • Fit survival curves and run cost-effectiveness or budget-impact models.
  • Prepare HTA evidence and dossier drafts for named regulatory and payer contexts.
  • Maintain searchable project evidence in raw and wiki file trees.

The tool inputs and outputs should be reviewed by qualified HEOR, clinical, statistical, and regulatory specialists before being used in a submission or decision. Model results depend on the assumptions and evidence supplied to each call.

Read the full README View source on GitHub

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Frequently Asked Questions about Heor Agent MCP

Run `npx heor-agent-mcp` with Node.js 20 or later. Claude Desktop can be configured with `npx` as the command and `heor-agent-mcp` as its argument.

Yes. The README provides a Claude Desktop configuration using the server's npm package over stdio.

Its separate hosted web UI requires the user's Anthropic API key.

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