Ncbi Variation vs Puumed

In-depth architectural comparison of the Ncbi Variation and Puumed MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

Which MCP Server Should You Choose?

N

Choose Ncbi Variation when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Ncbi Variation Details

Choose Puumed when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Puumed Details

Feature & Specification Comparison

Specification	N Ncbi Variation Biology & Bioinformatics	Puumed Biology & Bioinformatics
Summary	dbSNP refSNP records and HGVS/SPDI/rsID normalization for human genetic variants, from NCBI…	PubMed MCP — wraps the NCBI E-utilities API (biomedical literature, free, no auth)
Category & Scope	Biology & Bioinformatics	Biology & Bioinformatics

Tools & Capabilities Breakdown

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

{
  "mcpServers": {
    "ncbi-variation": {
      "command": "npx",
      "args": [
        "-y",
        "ncbi-variation"
      ]
    }
  }
}

{
  "mcpServers": {
    "puumed": {
      "command": "npx",
      "args": [
        "-y",
        "@pipeworx/mcp-pubmed"
      ]
    }
  }
}

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