Medplum MCP vs Prism

In-depth architectural comparison of the Medplum MCP and Prism MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

Which MCP Server Should You Choose?

Choose Medplum MCP when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer remote streaming HTTP/SSE transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Medplum MCP Details

P

Choose Prism when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Prism Details

Feature & Specification Comparison

Specification	Medplum MCP Biology & Bioinformatics	P Prism Biology & Bioinformatics
Summary	Securely access and manage FHIR healthcare data stored in Medplum.	Local-first repo intelligence for agents: DNA, health, blast radius, and Dispatch jobs.
Category & Scope	Biology & Bioinformatics	Biology & Bioinformatics
Quality signal

Tools & Capabilities Breakdown

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

{
  "mcpServers": {
    "mcp-112": {
      "url": "https://www.medplum.com"
    }
  }
}

{
  "mcpServers": {
    "prism": {
      "command": "npx",
      "args": [
        "-y",
        "prism"
      ]
    }
  }
}

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