Interpro vs Protein MCP Server

In-depth architectural comparison of the Interpro and Protein MCP Server MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

Which MCP Server Should You Choose?

I

Choose Interpro when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer remote streaming HTTP/SSE transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).
• Primary tools included: search_entries, get_entry, entries_for_protein.

Explore Interpro Details

Choose Protein MCP Server when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Protein MCP Server Details

Feature & Specification Comparison

Specification	I Interpro Biology & Bioinformatics	Protein MCP Server Biology & Bioinformatics
Summary	InterPro MCP (EBI) — protein family / domain / functional-site classification.	Federated protein structure & function across experimental (PDB) and predicted (AlphaFold) models.
Category & Scope	Biology & Bioinformatics	Biology & Bioinformatics

Tools & Capabilities Breakdown

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

{
  "mcpServers": {
    "interpro": {
      "url": "https://pipeworx.io"
    }
  }
}

{
  "mcpServers": {
    "protein-mcp-server": {
      "command": "bunx",
      "args": [
        "@cyanheads/protein-mcp-server@latest"
      ]
    }
  }
}

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