Cbioportal vs Mesh

In-depth architectural comparison of the Cbioportal and Mesh MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

Which MCP Server Should You Choose?

Choose Cbioportal when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer remote streaming HTTP/SSE transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Cbioportal Details

Choose Mesh when:

• You need dedicated capabilities in the Biology & Bioinformatics domain.
• You prefer remote streaming HTTP/SSE transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Mesh Details

Feature & Specification Comparison

Specification	Cbioportal Biology & Bioinformatics	Mesh Biology & Bioinformatics
Summary	cBioPortal MCP — cancer genomics portal.	NLM MeSH (Medical Subject Headings) MCP.
Category & Scope	Biology & Bioinformatics	Biology & Bioinformatics
Quality signal

Tools & Capabilities Breakdown

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

{
  "mcpServers": {
    "cbioportal": {
      "url": "https://pipeworx.io"
    }
  }
}

{
  "mcpServers": {
    "mesh": {
      "url": "https://pipeworx.io"
    }
  }
}

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