Ensembl MCP Server vs Skill of Skills

In-depth architectural comparison of the Ensembl MCP Server and Skill of Skills MCP servers. Compare execution transports, security boundaries, tool capabilities, quality scores, and ready-to-paste client installation snippets for Claude, Cursor, Windsurf, and VS Code.

Which MCP Server Should You Choose?

Choose Ensembl MCP Server when:

• You need dedicated capabilities in the Developer Tools domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Ensembl MCP Server Details

Choose Skill of Skills when:

• You need dedicated capabilities in the Developer Tools domain.
• You prefer local stdio subprocess transport architecture.
• Your security boundary fits: No auth required (Free / Open Source).

Explore Skill of Skills Details

Feature & Specification Comparison

Specification	Ensembl MCP Server Developer Tools	Skill of Skills Developer Tools
Summary	Look up genes, fetch sequences, predict variant consequences, find orthologs and xrefs via Ensembl.	Quality-ranked, cross-platform directory of AI coding skills, plugins and MCP servers.
Category & Scope	Developer Tools	Developer Tools

Tools & Capabilities Breakdown

Ready-to-Paste Client Configurations

Paste either (or both) of these JSON server blocks into your client config file (e.g. claude_desktop_config.json or ~/.cursor/mcp.json).

{
  "mcpServers": {
    "ensembl-mcp-server": {
      "command": "bunx",
      "args": [
        "@cyanheads/ensembl-mcp-server@latest"
      ]
    }
  }
}

{
  "mcpServers": {
    "skill-of-skills": {
      "command": "npx",
      "args": [
        "-y",
        "skills"
      ]
    }
  }
}

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